IMPLICATIONS AND POTENTIAL ROLE OF HUMAN TELOMERASE REVERSE TRANSCRIPTASE (HTERT) IN BLADDER CARCINOGENESIS
نویسندگان
چکیده
Bladder cancer is a heterogeneous disease and ranks as 10th most common worldwide. Urothelial carcinoma (UC) the histologic type of BC majority constitute papillary tumors that are well-differentiated (low-grade). Several genetic changes may occur in bladder cancer, but hTERT promoter mutations its expression has been detected cases transitional cell carcinoma. Numerous researches have led to findings which suggest conjunction with polymorphism potential being used clinical biomarkers cancer. Further studies need explore use gene detection, diagnosis prognosis. This review focuses on role backdrop various published.
منابع مشابه
Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms.
Ten percent of fine-needle aspirations (FNAs) of the thyroid are deemed "indeterminate" or "suspicious" for malignancy by the cytopathologist, but most of these lesions are benign. Therefore, additional markers of malignancy may prove to be a useful adjunct. The catalytic component of telomerase, human telomerase reverse transcriptase (hTERT), has been found to be reactivated in immortalized ce...
متن کاملTranscription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%-90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely. Telomerase Reverse Transcriptase (TERT), the catalytic subunit of tel...
متن کاملHuman telomerase reverse transcriptase (hTERT) gene expression in thyroid carcinoma: diagnostic and prognostic role.
BACKGROUND The catalytic component of telomerase, human telomerase reverse transcriptase (hTERT) has been found to be reactivated in immortalized cell lines and considered as a diagnostic marker for malignancy in different body tissues. AIM OF WORK Therefore we thought to determine whether hTERT gene detection could serve as an adjunct in the diagnosis of thyroid lesions together with evaluat...
متن کاملThe Potential Clinical Implications of Telomerase Reverse Transcriptase in the Detection and Diagnosis of Bladder Cancer
Telomerase and the control of telomere length are intimately linked to the process of tumorigenesis in humans and mutations in the promoter regions of its catalytic subunit, TERT, can affect telomerase activity and telomere, creating severe clinical phenotypes. In this paper, we briefly review the potential mechanisms under which TERT play in tumorigenesis and focus mainly on TERT’s potential a...
متن کاملHuman Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo
BACKGROUND Telomerase is a reverse transcriptase that maintains the telomeres of linear chromosomes and preserves genomic integrity. The core components are a catalytic protein subunit, the telomerase reverse transcriptase (TERT), and an RNA subunit, the telomerase RNA (TR). Telomerase is unique in its ability to catalyze processive DNA synthesis, which is facilitated by telomere-specific DNA-b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International journal of advanced research
سال: 2021
ISSN: ['2707-7802', '2707-7810']
DOI: https://doi.org/10.21474/ijar01/13031